Mercu tanda paling popular di Santa Ana ialah Gerry's Restaurant & Bar - Nono's Place Mexico Pampanga, Santa Ana Parish Church - San Joaquin, Sta. Ana, Pampanga, Kusinang Matua ng Atching Lillian Borromeo, McDonald’s - Sta Ana, Adelyn U. Sahagun, MD, FPOGS OB-GYN Clinic